• Don't administer tramadol hydrochloride extended-release tablets in a dose exceeding three hundred mg each day.The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors on levels of tramadol and M1 from tramadol hydrochloride tablets are complex. Usage of cytochrome P450 3A4 inducers, 3